Analysis of inhomogeneity of electrospun mat and its mitigation with the development of spirograph based collector a case study for wound dressing application

Abstract

Nanofibre polymeric scaffolds have been used for nanobased therapeutics in skin tissue regeneration and other fields of tissue engineering. Production of nanofibrous scaffolds from electrospinning technique is one of the simplest methods and it also facilitates to incorporate any desired antibiotics to achieve the enhanced biological response Electrospun polymeric substrates offer better properties such as surface topography fibre orientation surface modification fine porosity and optimum mechanical strength for the injured tissue to regenerate The mechanical property plays a vital role in the electrospun wound scaffold The wound scaffold requires more mechanical property in the places like knee elbow and also in wounds having more exudates Further required areas are the construction of tissue engineered urethras corneal wound and regeneration of female pelvic tissues cardiac tissue engineering neural tissue engineering lungs blood vessels etc This research work is based on the development of Spirograph Based Mechanical System SBMS for the collector assembly of electrospinning process The collector plate is set to trace a spiropath such a way that the event of crossing the centre radially is highest Chitosan and Polyethylene Oxide PEO polymer solution electrospun mat was prepared by SBMS and the properties of mat sectioned from the different angular position from circular mat were evaluated and compared with the mat from static aluminium foil collector Based on Scanning Electron Microscopy SEM image of the mat the fibre diameter and fibre alignment were analyzed using ImageJ software The electrospun mats demonstrate near uniform characteristics like thickness tensile strength porosity fibre diameter and alignment compared to the conventional static collector plate SBMS based electrospun mat proved better performance in wound healing newline