Templation cellular dynamics and toxicity of multifunctional poly lactic co glycolic acid plga nanoparticulate delivery systems

Abstract

The present thesis describes the results of comprehensive studies to demonstrate the imperative application of polymeric nanostructured frameworks. The entire thesis is distributed into seven parts that rationalize the templation, cellular dynamics, toxicity, and real-time application of PLGA-based nanoparticle. The present thesis primarily focuses on introducing the varied underlying aspects, and intermittent terminologies of nanoscience, and nanotechnology. The current thesis also comprises of literature review illustrating the importance of PLGA nanoparticles/PLGA-metal nanocomposites in the vibrant field of drug delivery and bacterial pathogenesis. The present work elaborates central composite design (CCD) based systematic optimization of all the requisite formulation parameters which can prove to be remarkably beneficial in achieving the desired physiochemical attributes. newlinePost optimization, the course of work have been directed towards the fabrication of surface engineered polymeric nanoparticulate systems encompassing diverse therapeutic agents. Outcome of the in vitro, in vivo and ex vivo studies depicted that these hybrid nanostructured systems can act as a versatile, and potent vector for cancer therapeutics. Taking the work one step ahead, hybrid polymer-metal nanocomposites have also been fabricated and their real time application was intrigued. The fabricated systems depicted excellent antibacterial, and photocatalytic properties thus, vouching the desired goal of the study. It can be righteously proclaimed from the outcome of the study that the present nanoparticulate system tends to offer a novel approach which can prove to be a benchmark in combating several deleterious diseases owing to which the health care sector can immensely benefitted. newline newline