Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/292980
Title: | Design and evaluation of gastroretentive drug delivery systems of anti hypertensives |
Researcher: | Vishnu Pulavarthy |
Guide(s): | Naveen Babu K |
Keywords: | Immunology Life Sciences Pharmacology and Pharmacy |
University: | Jawaharlal Nehru Technological University, Hyderabad |
Completed Date: | 2016 |
Abstract: | Gastroretentive Drug delivery systems are designed to prolong the gastric residence time after oral administration at specific site and controlling the release of drug, especially for achieving controlled plasma level as well as improving bioavailability. In the present work, an attempt was made to develop Gastroretentive tablets of Eprosartan mesylate, Valsartan and Candesartan cilexetil. These drugs are angiotensin-receptor blockers (ARB) widely prescribed in a variety of cardiac conditions like hypertension, diabetic nephropathy and heart failure. The biological half-life of Eprosartan mesylate is 5-7hours, Valsartan is 3-8 hours and Candesartan cilexetil is 6-9hours. All the above drugs have their maximum absorption in the initial part of gastro intestinal tract, which favours the development of gastro retentive floating dosage form. newline |
Pagination: | 240p. |
URI: | http://hdl.handle.net/10603/292980 |
Appears in Departments: | Faculty of Pharmaceutical Sciences |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
01_title.pdf | Attached File | 353.54 kB | Adobe PDF | View/Open |
02_declaration.pdf | 240.61 kB | Adobe PDF | View/Open | |
03_certificate.pdf | 415.3 kB | Adobe PDF | View/Open | |
04_acknowledgement.pdf | 497.06 kB | Adobe PDF | View/Open | |
05_abstract.pdf | 174.23 kB | Adobe PDF | View/Open | |
06_contents.pdf | 228.1 kB | Adobe PDF | View/Open | |
07_list of tables_figures.pdf | 265.99 kB | Adobe PDF | View/Open | |
08_chapter 1.pdf | 453.25 kB | Adobe PDF | View/Open | |
09_chapter 2.pdf | 159.93 kB | Adobe PDF | View/Open | |
10_chapter 3.pdf | 130.42 kB | Adobe PDF | View/Open | |
11_chapter 4.pdf | 229.36 kB | Adobe PDF | View/Open | |
12_chapter 5.pdf | 1.08 MB | Adobe PDF | View/Open | |
13_chapter 6.pdf | 2.49 MB | Adobe PDF | View/Open | |
14_chapter 7.pdf | 190.2 kB | Adobe PDF | View/Open | |
15_references.pdf | 359.69 kB | Adobe PDF | View/Open | |
80_recommendation.pdf | 536.44 kB | Adobe PDF | View/Open |
Items in Shodhganga are licensed under Creative Commons Licence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0).
Altmetric Badge: