Design Syntheses and Study of Photo Physical Properties of Aggregation Induced Emission active Compounds Applications in Bio imaging and Mechanoluminescence

Abstract

The thesis entitled Design, Syntheses and Study of Photo Physical Properties of Aggregation newlineInduced Emission active Compounds: Applications in Bio-imaging and Mechanoluminescence newlinedeals with the synthesis of new organic and platinum(II) based metal complexes which is newlinestructurally characterized and exhibited a unique Aggregation Induced Emission (AIE) newlineproperty. The synthesized complexes were used in different applications such as newlineMechanouminescence and Bioimaging. The thesis is divided in five chapters. newlineThe Chapter 1 of the thesis describes a literature overview about the fundamentals of newlinefluorescence and phosphorescence, various types of transitions such as MLCT, LLCT etc. newlineAdditionally the chapter describes the history of AIE active compounds and their probable newlinemechanistic pathways. The general features of AIE active platinum(II) complexes are described newlinein this chapter. The background of applications of luminescent materials in bioimaging and newlinemechanoluminescence has been described in this chapter. newlineThe Chapter 2 of the thesis describes the materials and instruments have been used to newlinecomplete the whole thesis work. newlineThe Chapter 3 The chapter consists of three parts. newlineChapter 3A, describes the simple methodology of synthesis of a water soluble newlineplatinum(II) based complex. The solid state emission of the complex is different from its newlinesolution state which arises due to the formation of a new electronic state, 3MLLCT. This newlinecomplex spontaneously enters into cell cytoplasm and then localize preferably into cell nucleus. newlineThe cellular uptake of Pt(II) complex by cancerous cells was observed higher as compared to newlinethe normal cells. Low cyto-toxicity of this complex facilitates for the possible application as newlinebio-imaging probe. newlineIn Chapter 3B, we have reported the syntheses of three AIE active cyclometalated newlinecomplexes, [Pt(C^N)(CH^N)Cl] (1), [Pt(C^N)P^P]Cl where [C^N = 2-phenylpyridine; P^P newlineis bis(diphenylephasphino)ethane (2) and cis- 1,2-Bis (diphenylephasphino)ethene (3)] and newlinestudy of their photophyscial properties. The co