Palladium catalyzed CC and CN bond formation of nucleosides quinazolines benzotriazoles and their biological activity

Abstract

The thesis consists of the modification of nucleosides, quinazolines and benzotriazoles. The work is also focused on C-C and C-N cross coupling reactions via Suzuki- Miyaura cross coupling and newlineBuchwald aminations in presence palladium catalysts/ligands. To develop the methodology for Suzuki and Buchwald coupling on nucleosides, quinazolines and benzotriazoles we have done the newlinecatalytic screening using variety of palladium catalysts in the combination of different ligands in presence of different bases and solvents. After establishing the suitable conditions, we have deployed newlinedifferent boronic acids for C-C coupling and different amines for C-N couplings. Obtained quinazoline derivatives were screened for their alpha-glucosidase inhibition activity and antioxidant activity. We have demonstrated the construction of hydroxyl benzotriazoles in finest way and the first ever method for the deprotection of hydroxyl group using bispinacolato diboron in excellent yields. newline