Synthesis and studies of some new heterocyclic compounds

Abstract

The work incorporated in this thesis entitled „Synthesis andStudies of Some New Heterocyclic Compounds’ involves the synthesis of novel Quinazoline and Pyrimidine derivatives. Literature study reveals that these derivatives show different biological activities viz. antitubercular, analgesic, anti-inflammatory, anti-bacterial, antimalarial, anti-fungal, anti-tumour, anti-HIV etc. This has prompted us to work on this category of compounds. Therefore, in search of new fused heterocyclic compounds with potential pharmaceutical value and in association with our work on the application of microwave irradiations, we synthesized (1) 4-aryl-3,4,5,6-tetrahydrobenzo[h] quinazoline-2(1H)-thiones; (2) 2-(alkyl/aralkylthio)-4-aryl-1,4,5,6- tetrahydrobenzo[h]quinazolines; (3) 1,4-diaryl-1,4,5,6tetrahydrobenzo [h]quinazoline-2-thiols; (4) 4-aryl-1,3,4,5-tetrahydro-2H-indeno[1,2- d]pyrimidine-2-thiones; (5) 2-(alkyl/araalkylthio)-4-aryl-4,5-dihydro- 1H-indeno[1,2-d] pyrimidines; (6) 1,4-diaryl-4,5-dihydro-1Hindeno[ 1,2-d]pyrimidine-2-thiols and their derivatives. Besides the synthetic part, some of the derivatives were screened for anti-bacterial activities. The antibacterial efficacy of the most effective extracts was compared with those of existing standard antibacterial antibiotics. Viz Amoxycillin and Ciprofloxacin. Seven different bacterial strains which were used as test organisms are: Pseudomonas fluorescence, Staphylococcus aureus, Acenetobactersp.,Bacillus subtilis, Staphylococcus epidermis, Salmonellatyphimurium TA 98, Escherichia coli