Studies on Some Heterocyclic Compounds of Medicinal Interest

Abstract

Background: In the projected study we identified biologically active scaffolds on newlinethe basis of literature survey and by viewing the current scenario of the research newlinefields. The work was mainly based on three different motifs triazole, purine and newlinebenzofuran. newlineAim: The target was to synthesize triazole and benzofuran derivatives which can newlinebe squared by their anti-cancer activity. The next target was to modify 2,6- newlinedichloropurine all these purine derivatives were used for their anti-tubercular newlinescreening. newlineMaterials and Methods: The synthesis of triazole derivatives was processed newlinethrough ugi multicomponent reaction by coupling of four various components. newlineThe 2,6-dichloropurine targeted molecules were synthesized by three step newlineprocess by adding triazole ring and hydrophobic alkyl chain. Oxygen and azide newlinefunctionality was introduced to benzofuran motifs by reaction of dimedone with newlinearomatic aldehyde and with 4-azidophenacyl bromide in a single step insitu newlineprocedure. newlineResults and Discussion: All these synthesized molecules were characterized newlineby various spectroscopy techniques such as Mass spectrometry, 1H NMR newlinespectroscopy, 13C NMR spectroscopy, Infrared spectroscopy and Single crystal newlineXRD study. newlineConclusions: The triazole and benzofuran derivatives were screened for their newlineanti-cancer activity using NCI-60 cell-lines using nine different cancer panels, newlinesome molecules showed appreciable activity for inhibiting cancer cell lines. The newline2,6-dichloropurine derivatives were screened against H37Rv antitubercular newlineactivity and showed considerable activity. newline