Isolation and solubility enhancement of bioactive constituents from Boswellia Serrata

Abstract

Boswellia serrata is a deciduous tree of family Burseraceae (Genus Boswellia). It is commonly known as Shallaki , Salai and Gajabhakshya . In India the Boswellia serrata is found in Andhra Pradesh, Gujarat, Madhya Pradesh, Jharkhand and Chhattisgarh (Shah et al. 2009; Moussaieff and Mechoulam 2009). The gum resin of Boswellia serrata is well known for its therapeutic benefits (Siddiqui 2011). Since ancient times Boswellia serrata resin extract has been used in folk medicine for its antiseptic, anti-arthritic and anti-inflammatory effects (Ammon 2006; Sharma et al. 1996; Poeckel and Werz 2006; Ismail et al. 2016; Qurishi et al. 2010; Singh and Atal 1986). Gum resin contains ethereal essential oils, non-polar terpenoids, and a greater amount of polysaccharides. The terpenoids part of resin consists of monoterpenes e.g. and#945;and#8208;thujene, and#945;and#8208;phellandrene, and#946;and#8208;phellandrene, and#945;and#8208;terpineol, diterpene alcohol e.g. serratol, tetracyclic triterpenic acid e.g. tirucallic acids, and pentacyclic triterpenic acids e.g. boswellic acids (Abdel-Tawab et al. 2011; Siddiqui 2011). newlineThe molecular formula of boswellic acids (BAs) is C32H52O4 with different functional groups (Al-Harrasi and Al-Saidi 2008). The different types of BAs are and#946;-boswellic acid (and#946;BA), acetyl-and#946;-boswellic acid (Aand#946;BA), 11-keto-and#946;-boswellic acid (KBA), acetyl-11-keto-and#946;-boswellic acid (AKBA) .Some tetracyclic triterpenes as tirucallic acids and a diterpenoic alcohol, serratol (Schmidt et al. 2011; Basar 2005; Mathe et al. 2004; Al-Harrasi and Al-Saidi 2008) are also present in the plant.