Study of Cytokine profile and TCF7L2 gene polymorphism in diabetes mellitus with chronic non healing ulcer

Abstract

Diabetes is an inherited non-communicable disease which occurs due to chronic newlinehyperglycemia or impairment in insulin secretion and action.1 It is a chronic disease newlineleading to diabetic nephropathy, atrial filtration, retinopathy, diabetic foot, newlineneuropathy, Coronary Vascular disease hypertension, cholecystectomy, pancreatitis, newlineUrinary Tract Infection. Diabetes can be classified as type 1 diabetes mellitus newline(T1DM), type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). newlineT2DM is the most heterogeneous type of disease which occurs due to insulin newlineresistance and reduced insulin secretion with a very high prevalence in comparison to newlineT1DM and gestational diabetes mellitus.2 newlineGenome wide association studies (GWAS) have played a primary role in newlinedemonstrating that genetic variation in a number of loci, as assessed by single newlinenucleotide polymorphisms, affects the risk of type 2 diabetes mellitus (T2DM). newlineAmong these, rs7903146, an intronic variant of the TCF7L2 (Transcription Factor 7 newlineLike 2) gene, is possibly the strongest known genetic risk factor for T2DM (O.R. newline=1.37). Each risk variant, however, per se contributes quantitatively little to the newlineoverall risk and is often of questionable biological significance in affecting the newlinedeterminants of glucose regulation. newlineOBJECTIVES newlineTo Study the polymorphic status of candidate gene TCF7L2 and association of SNP newliners7903146 polymorphism with particular secondary complication of T2DM and newlineT1DM i.e., diabetic foot ulcers patients in comparison to control population. newline