Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/275526
Title: Zidovudine and efavirenz induced teratogenicity in mice
Researcher: Mishra, Anand
Guide(s): Pandey, Shashi Kant
Keywords: Teratogenicity in Mice
University: Banaras Hindu University
Completed Date: 2017
Abstract: Introduction: newlineZidovudine (ZDV) is a thymidine analogue which has a potent activity both against HIV-1 and HIV-2 virus. It acts by inhibiting reverse transcriptase enzyme and by inhibiting viral DNA chain elongation. Efavirenz (EFV) is a non nucleoside reverse transciptase inhibitor which binds to reverse transciptase enzyme resulting in its allosteric inhibition. Both are constituent of highly active anti retroviral therapy (HAART) used for preventing maternal to child transmission of HIV virus. Zidovudine is classified as class C drug which means that although safe in animals it is yet to be tested in humans for reproductive toxicity. Efavirenz has been classified as class D drug which means that there has been reports of reproductive toxicity induced by it and should be used only when potential benefits outweigh the risk. As the teratology profile of both these drug has not yet been established so we have taken this study to ascertain the toxicity caused by both these drugs individually as well as in combination on structural, biochemical as well as on behavioural aspects of fetal mice. newline
URI: http://hdl.handle.net/10603/275526
Appears in Departments:Department of Physics

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02_abstract.pdf179.92 kBAdobe PDFView/Open
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04_acknowledgement.pdf55.47 kBAdobe PDFView/Open
05_content.pdf242.73 kBAdobe PDFView/Open
06_preface.pdf161.3 kBAdobe PDFView/Open
07_chapter 1.pdf571.56 kBAdobe PDFView/Open
08_chapter 2.pdf500 kBAdobe PDFView/Open
09_chapter 3.pdf737.87 kBAdobe PDFView/Open
10_chapter 4.pdf365.5 kBAdobe PDFView/Open
11_chapter 5.pdf689.57 kBAdobe PDFView/Open
12_chapter 6.pdf187.44 kBAdobe PDFView/Open
13_chapter 7.pdf220.32 kBAdobe PDFView/Open
14_bibliography.pdf97.15 kBAdobe PDFView/Open
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