Spectroscopic investigation of the structure of benzimidazole derivatives and study of their biological activities

Abstract

The present work describes the synthesis of substituted benzimidazoles newlinetheir spectral characterisation and investigation of their biological activities newlineThe substituted benzimidazoles are prepared following the method of newlineHein et al The pTolyl benzimidazole is obtained when ortho phenylene newlinediamine is heated with pbenzoic acid pTolyl benzimidazole when treated newlinewith ethylbromoester yields 2pTolyl carbethoxy ester2pTolyl newlinebenzimidezolyl acetyl3hydrazide is prepared by treating 2pTolyl newlinecarbothoxy ester with hydrazide Compound I2pTolylN2phenyl134 newlineoxadiazolylmethyl benzimidazole compound II 2pTolylN2 phenyl134 newlineoxadiazolylmethyl benzimidazole compound III 2pTolylN2 anisyl134 newlineoxadiazolylmethyl benzimidazole and compound IV 2pTolylN2 newlinechlorophenyl134 oxadiazolylmethyl benzimidazole are synthesized by newlinetreating 2pTolyl benzimidazolyl acetyl3hydrozide with benzoic acid toluric newlineacid methoxy benzoic acid and chlorobenzic acid respectively newline