Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/271166
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dc.coverage.spatialBiochemistry
dc.date.accessioned2020-01-24T06:02:39Z-
dc.date.available2020-01-24T06:02:39Z-
dc.identifier.urihttp://hdl.handle.net/10603/271166-
dc.description.abstractSLE is a chronic systemic autoimmune inflammatory disease associated with a broad spectrum of clinical presentations. Various complications arise from an increase in inflammation and oxidative stress. The current therapies include anti-malarials, corticosteroids, immunosuppressants and NSAIDs. Resveratrol is a phytoalexin found in grapes, peanuts, etc. It is known for numerous pharmacological effects. It has potent anti-oxidative, anti-inflammatory, anti-cancer, immunomodulating properties. It has rapid absorption but low bioavailability. Piperine, a major active component of black and long peppers, is used as a bioenhancer for different drugs including resveratrol. The present study aimed to determine the combinatorial effect of resveratrol and piperine on murine model of lupus. Pristane injected murine model of lupus develop anti-nuclear antibodies but none of treatments could abrogate ANA formation. Immune complexes were formed in kidneys, liver, lungs, spleen and skin. RP- 1 in kidneys, RP-1 and P-Res in liver, Res-2, RP-2, P-Res and P-RP in lungs and none of the treatments showed positive results in abrogating immune complexes in spleen and skin. Treatments newlineabrogating histopathological manifestations were RP-1, Res-2 and P-Res in kidneys, RP-1, P-Res and P-RP in liver, Res-2, P-Res and P- RP in lungs and none in spleen and skin. Oxidative stress was successfully combated by almost all the doses of resveratrol. Inflammation was regulated by decreasing level of IL-6 by RP-1 and P-Res and TNF-and#945; by RP-1, Res-2, P-Res and P-RP. Renal pathologies were improved by mitigating proteinuria by RP-1, Res-2, RP-2, P-Res and P-RP and by increasing creatinine level in urine by RP-1 and P-RP. Lipogranulomas were abrogated by RP-1, Res-2 and P-Res. These findings stated that even a low dose of resveratrol when used in combination with piperine is potent to combat lupus associated manifestations and a low dose of resveratrol, alone serves as a prophylactic measure to prevent various manifestations of lupus.
dc.format.extent201p.
dc.languageEnglish
dc.relation-
dc.rightsuniversity
dc.titleCombinatorial effect of resveratrol and piperine in murine model of systemic lupus erythematosus
dc.title.alternative-
dc.creator.researcherPannu, Naveet
dc.subject.keywordInflammation
dc.subject.keywordLife Sciences,Biology and Biochemistry,Biochemistry and Molecular Biology
dc.subject.keywordOxidative Stress
dc.subject.keywordPiperine
dc.subject.keywordResveratrol
dc.subject.keywordSystemic Lupus Erythematosus
dc.description.noteReferences p.170-201
dc.contributor.guideBhatnagar, Archana
dc.publisher.placeChandigarh
dc.publisher.universityPanjab University
dc.publisher.institutionDepartment of Biochemistry
dc.date.registered07/04/2014
dc.date.completed2019
dc.date.awardedn.d.
dc.format.dimensions-
dc.format.accompanyingmaterialCD
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Biochemistry

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04_contents.pdf16.32 kBAdobe PDFView/Open
05_list of tables.pdf62.81 kBAdobe PDFView/Open
06_list of figures.pdf96.45 kBAdobe PDFView/Open
07_abbreviations.pdf163.32 kBAdobe PDFView/Open
08_chapter 1.pdf258.71 kBAdobe PDFView/Open
09_chapter 2.pdf933.5 kBAdobe PDFView/Open
10_chapter 3.pdf459.07 kBAdobe PDFView/Open
11_chapter 4.pdf20.55 MBAdobe PDFView/Open
12_chapter 5.pdf305.35 kBAdobe PDFView/Open
13_chapter 6.pdf92.38 kBAdobe PDFView/Open
14_references.pdf451.37 kBAdobe PDFView/Open


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