Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/268260
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dc.date.accessioned2020-01-08T12:09:04Z-
dc.date.available2020-01-08T12:09:04Z-
dc.identifier.urihttp://hdl.handle.net/10603/268260-
dc.description.abstractCancer becomes one of the leading causes of morbidity and mortality worldwide and according to World Health Organization (WHO) it will be an alarming situation by 2020. Different approaches have been used to treat cancer but for advanced stages of cancer, effective therapeutic regimen is very essential to be developed. However, continuous efforts are going on to develop new anticancer drugs with novel mechanisms of action to cure the malignancy and also to conquer the side effects and limitations of existing drugs. The discovery of anticancer activity of cisplatin stimulated the research in the area of metal-based antitumor drugs worldwide. In recent years, several other metals (non-platinum) complexes have been extensively investigated for their antitumor activity and it has been observed that the derivatives of ruthenium, rhodium and iridium may develop as possible anticancer chemotherapeutics. Two ruthenium drugs, NAMIand#8208;A and KP1019 are currently in clinical trials. NAMIand#8208;A is an arene Ru drug and antitumor metastatic inhibitor in nature. KP-1019 is activated through hypoxic environment and both drugs described above are well tolerated by patients. Studies on Ru, Rh and Ir complexes offer development of new anticancer chemotherapeutic regimens and also display the selective capabilities without systemic toxicity. On the basis of these facts it worthy to undertake this investigation on anticancer activity of novel Ru, Rh and Ir arene complexes (20 complexes of three different series) and following objectives were being made: newline newlineObjectives 1. Evaluation of cytotoxicity and antiproliferation activity of arene complexes in vitro and in vivo. 2. Detection of apoptotic induction and effect on cell cycle phase distribution. 3. To determine the possible molecular mechanism of anticancer activity of arene complexes. newline
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dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleStudies on Anticancer activity of novel transition metal arene complexes invitro and invivo
dc.title.alternative
dc.creator.researcherSharma, Gunjan
dc.subject.keywordLife Sciences,Biology and Biochemistry,Cell Biology
dc.description.note
dc.contributor.guide
dc.publisher.placeVaranasi
dc.publisher.universityBanaras Hindu University
dc.publisher.institutionDepartment of Zoology
dc.date.registered1-9-2010
dc.date.completed2016
dc.date.awarded
dc.format.dimensions
dc.format.accompanyingmaterialCD
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Zoology

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00 thesis abstract final.pdfAttached File122.58 kBAdobe PDFView/Open
01 thesis introduction .pdf299.23 kBAdobe PDFView/Open
02 chapter 1 .pdf666.82 kBAdobe PDFView/Open
03 chapter 2 .pdf732.21 kBAdobe PDFView/Open
04 chapter 3 .pdf249.93 kBAdobe PDFView/Open
05 summary and conclusion .pdf31.03 kBAdobe PDFView/Open
06 references .pdf90.23 kBAdobe PDFView/Open


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