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http://hdl.handle.net/10603/267608
Title: | Development and evaluation of formulations for h Pylori infection management |
Researcher: | Dumbre, S.Y. |
Guide(s): | Momin, M. |
Keywords: | drug delivery system enteric coating floating drug delivery system Gastroretentive gastroretentive patch H. pylori Lansoprazole Metronidazole microspheres Social Sciences,Economics and Business,Management |
University: | RK University |
Completed Date: | 23/09/2019 |
Abstract: | H. Pylori gram negative bacteria spread over the world is a main causative pathogen for gastritis leading to gastric cancer. Infection requires complicated treatment of combination of antibiotics with proton pump inhibitor to be given three to four times a day for 7 to 14 days which reduces patient compliances as well sequential dosing increases manufacturing and packing cost. Further organism resides deep inside the mucosal layer so for better eradication needs site specific delivery of the drugs. Aim of the research work was to develop single unit dosage form like capsule or tablet containing combination of or Metronidazole and Lansoprazole in different dosage forms like triple layer tablet , multiparticulate system containing enteric coated Lansoprazole granules and floating alginate beads of Metronidazole and gastro retentive sandwich patch with Lansoprazole enteric coated granules using different semi-synthetic or synthetic polymers. Formulations were evaluated for required in-vitro studies like hardness, friability, Floating lag time, mucoadhesion and dissolution study etc for triple layer tablet while floating time, mucoadhesion , particle size, swelling index, % entrapment for multiparticulate dosage form and folding endurance, tensile strength, dissolution profile for expandable patch of Metronidazole along with enteric coated granules of Lansoprazole to determine their efficacy for management of H. Pylori infection. Work also includes development and validation of simultaneous analytical method for determination of Metronidazole and Lansoprazole using RP-HPLC according to ICH guidelines. After comparing all three formulations it was observed that research work had achieved mentioned objectives of reducing number of dosage forms to increase patient compliance as well as enhance efficacy of the formulation by specific drug delivery to stomach by developing and optimising triple layer tablet containing Metronidazole and Lansoprazole together. Present research work will further surely help in reducing |
Pagination: | - |
URI: | http://hdl.handle.net/10603/267608 |
Appears in Departments: | Faculty of Management |
Files in This Item:
File | Description | Size | Format | |
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10 graphical abstract.pdf | Attached File | 78.39 kB | Adobe PDF | View/Open |
11 chapter 1-introduction_n.pdf | 370.74 kB | Adobe PDF | View/Open | |
12 chapter 2- literature review_n.pdf | 105.91 kB | Adobe PDF | View/Open | |
13 chapter 3- research problem, material_n.pdf | 111.62 kB | Adobe PDF | View/Open | |
14 chapter 4- experimental method_n.pdf | 432.5 kB | Adobe PDF | View/Open | |
15 chapter 5-result and discussion_n.pdf | 2.51 MB | Adobe PDF | View/Open | |
16 list of publications_n.pdf | 25.55 kB | Adobe PDF | View/Open | |
17 references_n.pdf | 144.1 kB | Adobe PDF | View/Open | |
1cover page_n.pdf | 40.98 kB | Adobe PDF | View/Open | |
2 certificate_n.pdf | 106.99 kB | Adobe PDF | View/Open | |
3 declaration_n.pdf | 68.28 kB | Adobe PDF | View/Open | |
4 acknowledgement_n.pdf | 73.41 kB | Adobe PDF | View/Open | |
5 tableof content_n.pdf | 64.59 kB | Adobe PDF | View/Open | |
6 list of tables.pdf | 80.8 kB | Adobe PDF | View/Open | |
7 list of figures.pdf | 81.41 kB | Adobe PDF | View/Open | |
8 list of abbreviations.pdf | 72.22 kB | Adobe PDF | View/Open | |
9 abstract_n.pdf | 11.25 kB | Adobe PDF | View/Open |
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