Development and Evaluation of Novel Chitosan Based Nanocomposite Films for Wound Healing

Abstract

Wound healing progresses through a sequence of interdependent and overlapping phases in newlinewhich a variety of cellular, biochemical, and matrix components act together not only to restore newlinethe integrity of damaged skin and tissue but also to replace the lost tissue. Chitosan plays a newlinesignificant role in wound healing process due to its exciting and remarkable biological newlineproperties. It is a natural polysaccharide used for various biomedical and pharmaceutical newlineapplications. Various blends of natural polymers including chitosan have been developed by newlinemany researchers for their potentials uses in diverse biomedical applications. But still these do newlinenot fulfill all the criteria when especially considered for wound healing purposes. It is because of newlinetheir poor water absorption capacity and poor mechanical properties as well. Therefore, to newlineovercome all the drawbacks associated with the existing wound dressing materials, in this newlinepresent work, chitosan-clay based nanocomposite films were prepared by conventional solution newlinecasting method for wound healing application. Amoxicillin trihydrate was incorporated into the newlineoptimized solution mixture of chitosan-clay. The optimization of nanocomposite film without newlinedrug was performed on the basis of folding endurance, water absorption, water vapour newlinetransmission rate (WVTR), and porosity newline