Design of Magnetic Microbullets Using Novel Hybrid Technology for the Treatment of Rheumatoid Arthritis

Abstract

Drug delivery is a science which requires the development oftailored systems that can deliver defined quantities of a therapeutic payload ata specific target site, at a controlled release rate, with or without a specifictrigger. However, several drug molecules cannot be formulated oradministered by standard techniques as they exhibit poor water solubility orhave limited stability in the human body. Polymeric multilayer capsules newlineassembled using Layer-by-Layer technique (LbL) are promising candidatesfor complex tasks, such as, storage, encapsulation and release. These carrierscan be readily engineered and functionalized with desired properties and arealso flexible for specific changes with respect to mechanical stability,elasticity, morphology, biocompatibility, permeability and surfacecharacteristics. Multifunctionality and its ability to respond to various stimulithat can affect and control their properties are the most significant advantagesof Poly Electrolyte Multilayer (PEM) capsules. Aim of the present study was newlineto develop a Fe-drug loaded micro bullets using a novel hybrid technology formagnetic targeted therapy and its comparative evaluation on rheumatoidarthritis. Methotrexate Magnetic Microcapsules (MMC) and PrednisoloneMagnetic Microcapsules (PMC) was developed using the techniques detailedbelow. Poly(Sodium 4-Styrenesulfonate) (PSS) doped porous CaCO3 coremicroparticles were prepared by biomimetic mineralization method and itssurface morphology was observed and analysed using SEM, followed by newlinewhich, particle size distribution, zeta potential, functional groupcharacterization, thermal stability, porosity and crystallini newline newline