Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/258824
Title: | Development of self nanoemulsifying drug delivery systems for the enhancement of oral bioavailability of lipophilic drugs |
Researcher: | Sharavanan Sp |
Guide(s): | Subramanian N |
Keywords: | Bioavailability Clinical Pre Clinical and Health,Clinical Medicine,Medicine General and Internal Lipophilic Drugs |
University: | Anna University |
Completed Date: | 2018 |
Abstract: | Low bioavailability of lipophilic drugs remains a challenge in the treatment of all diseases. The objective of this research work was to formulate and characterize self-nanoemulsifying drug delivery systems (SNEDDS) containing Lacidipine (LCDP), Raloxifene Hydrochloride (RLFH) and Raloxifene Base (RLFB) to improve the oral bioavailability. Formulations were evaluated for solubility, self emulsification time, transparency, thermodynamic stability, cloud point, globule size, surface morphology, drug content, in-vitro dissolution, ex-vivo permeation, stability, oral bioavailability and lymphatic drug transport. In the development of LCDP SNEDDS, Captex 810D, Tocopherol Glycerol Succinate (TPGS), Tween-60, Transcutol P and Polyethylene Glycol (PEG) 400 was selected based on the solubility study. LCDP SNEDDS was prepared by simple mixing method and characterized for its in-vitro and invivo performance. In-vitro dissolution of SNEDDS showed more than 80 % newlineof drug release within 15 min. The ex-vivo permeation of LCDP from SNEDDS is 4.8- and 9-fold higher compared to LCDP suspension in the absence and presence of verapamil (P-gp and CYP inhibitor) respectively. The stability study of the SNEDDS confirmed no environmental effect on the physical nature and drug content. Oral bioavailability of LCDP with SNEDDS is 2.5 times higher compared to marketed tablet. newline newline newline |
Pagination: | xxiii, 153p. |
URI: | http://hdl.handle.net/10603/258824 |
Appears in Departments: | Faculty of Technology |
Files in This Item:
File | Description | Size | Format | |
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01_title.pdf | Attached File | 21.93 kB | Adobe PDF | View/Open |
02_certificates.pdf | 704.49 kB | Adobe PDF | View/Open | |
03_abstract.pdf | 6.95 kB | Adobe PDF | View/Open | |
04_acknowledgement.pdf | 4.04 kB | Adobe PDF | View/Open | |
05_table of contents.pdf | 41.36 kB | Adobe PDF | View/Open | |
06_list_of_symbols and abbreviations.pdf | 5.43 kB | Adobe PDF | View/Open | |
07_chapter1.pdf | 329.81 kB | Adobe PDF | View/Open | |
08_chapter2.pdf | 70.51 kB | Adobe PDF | View/Open | |
09_chapter3.pdf | 1.31 MB | Adobe PDF | View/Open | |
10_conclusion.pdf | 14.7 kB | Adobe PDF | View/Open | |
11_references.pdf | 80.46 kB | Adobe PDF | View/Open | |
12_list_of_publications.pdf | 8.33 kB | Adobe PDF | View/Open |
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