Phytosynthesis and characterization of copper oxide zinc oxide nanoparticles for antibacterial antioxidant anticancer in vitro drug release

Abstract

Greener eco-friendly processes becoming more popular and essential nowadays as a worldwide to encounter various environmental issues. Recent years, green nanotechnology explored as a powerful technology to develop innovative solutions, that is reliable and also sustainable for the existing global problems through research and development. Metal oxide nanoparticles currently exploited for numerous scientific research and technological applications. Green synthesis considered to be the most promising approach for production of metal oxide nanoparticles which possess unique properties such as catalytic, optical, magnetic and electrical properties. Although, several techniques were employed for nanoparticle synthesis, green synthesis using plants to obtain nanoparticles are eco-friendly and have sustainable benefits. Plants containing active secondary metabolites act as bioreducing agents and stabilize the synthesis of nanoparticles. Besides, plant based nanoparticles can also serve as potential candidate for large-scale synthesis. The present research focused on copper oxide and zinc oxide nanoparticles synthesis using Tecoma castanifolia and Cassia auriculata leaf extract. The as-synthesized nanoparticles were characterized by UV-visible spectroscopy, TEM with EDX, FTIR and XRD to confirm their optical, morphological, functional groups and crystalline nature. The phytochemical constituents present in leaf extract of Tecoma castanifolia and Cassia auriculata were analysed by GC-MS. The phytosynthesized CuO and ZnO nanoparticles were tested for their antibacterial activity against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus newline