An investigation of urinary tract infection and studies on antibacterial compounds of avicennia marina and in silico drug designing through molecular docking

Abstract

Urinary tract infection is a bacterial infection that affects any part of the urinary tract. It is a serious health problem affecting millions of people each year. It almost certainly affects one-half of all the people during their life time. The occurrence of this infection is greater in women as compared to men. Treatment of urinary tract infection is becoming difficult due to the rising trend of antibiotic resistant organisms. This phenomenon has great concern among the medical community in the developing countries. Thus current awareness on antibiotic resistance pattern is vital for appropriate treatment. Medicinal plants have been precious and important sources of natural products for the health of human beings and they have a great potential to be used as new therapeutic drugs. A number of mangroves and its associates possess biologically active compounds with antimicrobial properties. So they have the ability of curing infectious diseases. Owing to the wide applications of mangroves - Avicennia marina was analyzed for antibacterial activity against pathogens like Escherichia coli and Staphylococcus aureus isolated from urinary tract infected patients. The results revealed that the methanol extract of A. marina leaves showed effective antibacterial activity among other solvent extracts like water, hexane, chloroform and ethyl acetate against the pathogens. Thus the antibacterial compound present in the extract was isolated and identified as venlafaxine. newline