Studies on prunus cerasoides and albizia stipulata gums as versatile biocarriers for drug delivery applications

Abstract

The present study is focused on the exploitation of natural gums of Prunus cerasoides (PC) and Albizia stipulata (AS) as novel carriers in drug delivery applications. Biocompatible novel gums were used as carriers in different formulations such as mucoadhesive beads, matrix tablet and silver nanoparticles. Diclofenac Sodium (DS) loaded PC in combination with Sodium Alginate (SA) composite beads (DS-PC-SA) and Raloxifene hydrochloride (RLX) loaded AS and SA composite beads (AS-SA-RLX) were prepared by ionic gelation method and the result showed controlled release by prolonging the residence time in the gastrointestinal tract, thereby overcoming the problems associated with the immediate release dosage forms of DS and RLX, respectively. Other than mucoadhesive composite bead formulations, Paracetamol Matrix Tablets (PCMT) and Methotrexate (MTX) conjugated PC gum stabilized silver nanoparticles (PC-MTX-AgNps) were prepared and evaluated. PCMT formulation was optimized based on desired response variable Drug Release (DR). The optimized PCMT formulation showed favorable in vitro release of PC (65%) in 12 h, and the release newlinekinetics followed zero order anomalous diffusion mechanism. PCMT formulation remarkably potentiated the anticancer effect after 24 h treatment by inducing apoptosis. PC-MTX-AgNps were prepared by sunlight irradiation method and its anti-inflammatory property was evaluated. Optimized PCMTX- AgNps formulation decreased the pro-inflammatory mediators (nitric oxide and reactive oxygen species) in RAW264.7 macrophages, thereby exerting significant anti-inflammatory activity. Therefore, these studies pave way for exploring the natural gums of PC and AS as novel biopolymers for drug delivery in cancer therapeutics and inflammation research. newline newline