Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/258369
Title: Biomimetic fabrication of a native fibrillar collagen composite for bone tissue engineering
Researcher: Socrates R
Guide(s): Narayana Kalkura S
Keywords: Engineering and Technology,Engineering,Engineering Multidisciplinary
University: Anna University
Completed Date: 2018
Abstract: Due to increasing demand for bone implants, conventional tissue replacements cannot meet the quantity and performance needed by patients. Bone is a complex tissue composed of hydroxyapatite [Ca10(PO4)6(OH)2, HAp] and collagen. Approximately 30% of dry bone is oforganic materials, about 95% of which is collagen type I. Collagen, the main organic component of the Extracellular Matrix (ECM), induces positive effects on cellular attachment, proliferation, and differentiation of many cell types. As the main inorganic component of bone, HAp has been widely used in many orthopaedic and dental implant materials because of its bioactive, osteoconductive, and osteoinductive properties. Compared with other HApbiodegradable polymer composites, HAp-collagen composites have been approved as a bioactive and biodegradable scaffold due to their chemical and structural similarity to bone. Collagen-HAp composites are usually prepared by physical mixing of pre-synthesized HAp particles with collagen. Oyane et al. have also reported that modified Simulated Body Fluid (m-SBF) can be used for the preparation of biomimetic hydroxyapatite. However, collagen scaffolds prepared without reconstitution into native form as in the above mentioned studies, are inferior in mechanical property and wound healing applications. Another difficulty in calcified tissue repair is the probability of infection given the large surfaces exposed during hip implant surgery and silver ions have been shown to be effective in controlling this. Silver nanoparticles with high specific surface area having more efficient ion release can be incorporated onto collagen scaffolds to treat bone defects. newline
Pagination: xxiv, 120p.
URI: http://hdl.handle.net/10603/258369
Appears in Departments:Faculty of Technology

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02_certificates.pdf210.96 kBAdobe PDFView/Open
03_abstract.pdf12.88 kBAdobe PDFView/Open
04_acknowledgement.pdf7.62 kBAdobe PDFView/Open
05_table_of_contents.pdf23.74 kBAdobe PDFView/Open
06_list_of_symbols_and_abbreviations.pdf25.04 kBAdobe PDFView/Open
07_chapter1.pdf619.99 kBAdobe PDFView/Open
08_chapter2.pdf959.02 kBAdobe PDFView/Open
09_chapter3.pdf978.49 kBAdobe PDFView/Open
10_chapter4.pdf915.77 kBAdobe PDFView/Open
11_conclusion.pdf12.64 kBAdobe PDFView/Open
12_references.pdf65.11 kBAdobe PDFView/Open
13_list_of_publications.pdf8.64 kBAdobe PDFView/Open
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