Strategies for the Synthesis of New Chiral Pyrrolidine Based Organocatalytic Asymmetric CC Bond Formation Reactions

Abstract

In the present work, we have synthesized two new chiral pyrrolidine based newlineorganocatalysts and studied it s applications in the different organocatalytic newlineasymmetric C-C bond formation reactions for the synthesis of some heterocyclic newlinecompounds. The thesis work is divided into five chapters. The first chapter is divided newlineinto two sections, Section A deals with the introduction to field of organocatalysis and newlineSection B describes the synthesis and characterization of new chiral pyrrolidine based newlineorganocatalysts. Applications of these catalysts were studied in different chemical newlinetransformations i.e. organocatalytic asymmetric C-C bond formation reactions. newlineSecond chapter deals with the study of asymmetric synthesis of xanthenone newlinecompounds. It is divided into two sections, each section describing the details of the newlineasymmetric synthesis of one family of xanthenone skeleton. The third chapter is newlinedivided into two sections, Section A describes asymmetric synthesis of newlinebenzo[a]xanthene-11-one and benzo[a]acridine-11-one derivatives. Section B newlinedescribes asymmetric synthesis of dihydropyrano (c) chromene and pyrano [2,3-d]- newlinepyrimidine derivatives.. Chapter four is grouped into two sections: section A deals newlinewith organocatalytic enantioselective synthesis of optically active 7-aryl-11,12- newlinedihydrobenzo [H] pyrimido-[4,5-b]quinoline-8,10(7H,9H)-diones and organocatalytic newlineasymmetric synthesis of chromenyl phosphonates and dicyanophenylethyl newlinephosphonates was studied in section B. Asymmetric pyrrolidine based organocatalytic newline newline