Evaluation of cell free foetal DNA as a diagnostic marker of pre eclampsia

Abstract

The gestational age dependant increase of hypermethylated RASSF1A; the foetal specific epigenetic marker in maternal plasma was demonstrated in a study group of normal pregnant women and pre-eclampsia cases. Diagnostic potential of foetal specific, hypermethylated RASSF1A in pre-eclampsia was proved with high sensitivity and specificity. Its positive relationship with placental and urine proteins submitted the case for considering it as a reliable marker for pre-eclampsia. Findings would form the basis of future studies involving pregnancy complications that would aid in the early diagnosis of placental pathologies with hypermethylated RASSF1A. newline