Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/253149
Title: Design synthesis and characterization of stimuli responsive polymeric nanoparticles for targeted drug delivery
Researcher: Gover Antoniraj M
Guide(s): Ruckmani K
Keywords: Drug Delivery
Engineering and Technology,Engineering,Engineering Multidisciplinary
Polymeric Nanoparticles
Stimuli Responsive Polymeric Nanoparticles
synthesis stimuli responsive copolymers
University: Anna University
Completed Date: 2018
Abstract: newline Design of safe and efficient drug delivery system to administer therapeutic agents for life threatening diseases remains to be a major challenge in the field of drug delivery, where, the therapeutic agents are often associated with serious side effects of the drug exhibiting substantial toxicity to normal cells. Restriction to minimal dose of therapeutic agents is strategically used to avoid unwanted side effects, which leads to less effective treatment and associated drug resistance in the diseased cells. Nanomaterials, such as polymeric micelles, liposomes, nanogels, nanospheres and polymer drug conjugates, serve as one of the most recent and convenient technology to address the drawbacks associated with drug administration without any toxicity to the normal cells. These nanocarriers are capacitated to passively accumulate in tissues by enhanced permeation and retention (EPR) effect, thus, exhibiting enhanced therapeutic competence. For further improved target specific drug delivery, several recent research works have dedicated towards the development of stimuli-sensitive drug delivery system, where, the release of therapeutic moiety is regulated by physiological stimulus (such as pH, temperature, glutathione, etc.) after reaching the diseased site. The present work focuses on inflammation and lung cancer, where, the cellular microenvironment of an affected tissue is often different when compared to that of the normal tissues owing to accelerated atypical cellular metabolic reactions in the diseased cells.
Pagination: xxxiv , 222p
URI: http://hdl.handle.net/10603/253149
Appears in Departments:Faculty of Technology

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02_certificates.pdf1.26 MBAdobe PDFView/Open
03_abstract.pdf146.57 kBAdobe PDFView/Open
04_acknowledgement.pdf457.25 kBAdobe PDFView/Open
05_contents.pdf369.08 kBAdobe PDFView/Open
06_chapter1.pdf929.32 kBAdobe PDFView/Open
07_chapter2.pdf2.16 MBAdobe PDFView/Open
08_chapter3.pdf2.18 MBAdobe PDFView/Open
09_chapter4.pdf2.04 MBAdobe PDFView/Open
10_chapter5.pdf1.58 MBAdobe PDFView/Open
11_chapter6.pdf199.91 kBAdobe PDFView/Open
12_conclusion.pdf179.4 kBAdobe PDFView/Open
13_references.pdf486.47 kBAdobe PDFView/Open
14_publications.pdf404.45 kBAdobe PDFView/Open
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