Study of Biomarkers and Gene Polymorphism and their Association with Bone Mineral Density in Patients with Osteoporosis

Abstract

Osteoporosis becoming a major global health problem affected by 1 in 3 women over age 50 will experience osteoporotic fractures as 1 in 5 men aged over 50 years It is a silent disease the individuals with osteoporosis are at an increased risk of fractures resulting in major health and economic impact of the disease Aim is to study the association between bone biomarkers and gene polymorphism with bone mineral density in osteoporotic patients The bone mineral density bone biomarkers gene polymorphism and bone marrow fat were evaluated by various appropriate methods Statistical significant differences were observed in above mentioned parameters among the osteoporosis and normal bone mass group The study concludes that the decreased bone mineral density plays a key role in the development of osteoporosis The significant differences in bone biomarkers bone mineral density, gene polymorphism and bone marrow fat may suggest the interrelation between bone remodelling disturbances in the pathogenesis of osteoporosis newline