Investigation of multifunctional Bioactivity of a diarylheptanoid Isolated from alpinia officinarum in Cancer cell signaling an invitro study

Abstract

Inflammatory diseases involving multiple processes mediated by newlineactivated immune cells are becoming common throughout the world newlineEpidemiological and recent studies have indicated chronic infections and newlineinflammation as a major risk factor in various types of cancer and many of the newlinecancer deaths are linked to underlying infections and inflammatory reactions newlineBreast cancer is the common malignant neoplasm and is the second major newlinecause of cancer related death in women world wide newlinePleiotropic agents such as phytoprinciples have been reported to newlineexhibit significant impact on breast cancer prevention and or therapy by newlinetargeting both receptor positive and negative cancer cells A lower incidence newlineof breast cancer has been observed with high consumption of phytoestrogens newlinewhich are biologically active plant derived phenolic compounds structurally newlinemimicking the mammalian estrogen 17 Estradiol Pharmacologically newlineAlpinia officinarum belonging to Zingibeaceae family newlinepossess a very complex mixture of compounds such as gingerols caffeic acid newlineand curcumin Diarylheptanoids DAH are naturally occurring newlinephytochemicals in the rhizome part of Alpinia officinarum and are known to newlineexhibit multifunctional bioactivity for various diseases DAHs are used as newlinetraditional herbs for relieving stomach ache treating colds invigorating the newlinecirculatory system and for reducing swelling in China newline