Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/2514
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dc.coverage.spatialen_US
dc.date.accessioned2011-08-30T06:24:41Z-
dc.date.available2011-08-30T06:24:41Z-
dc.date.issued2011-08-30-
dc.identifier.urihttp://hdl.handle.net/10603/2514-
dc.description.abstractAlthough insulin was discovered over 85 years ago, the complications of diabetes still produce devastating consequences. An obvious path to prevention of complications is some kind of beta cell replacement therapy in the form of transplantation. Introduction of Edmonton protocol in the year 2000 provided better results in islet preparation, transplantation and improved immunosuppression. In-spite of this success, the supply of insulin producing cells, currently only from heart beating cadaver donor is insufficient and limits the extension of this therapy. Hence, the quest to find an alternative source of insulin producing cells that might be used for transplantation is intense. Rapid improvement in our understanding of the mechanism of cellular development and a wide array of potential stem/precursor cell candidates provide fuel for optimization of the short supply of insulin producing cells. newline An important issue of interest in stem cell studies is the availability of the source and the efficacy of isolation techniques to yield a reasonable amount of viable cells to expand. Although, embryonic stem (ES) cells showed some gene characteristics similar to normal beta cells; ethical issues surrounding ES cells are major concern. newline A variety of studies support the concept that adult stem cells can be directed to become insulin producing cells. Current claims about differentiation / transdifferentiation of adult stem cells to insulin producing cells includes pancreatic ductal cells, intra islet precursor cells, hepatic stem cells, neural progenitor cells, and bone marrow-derived cells. These adult stem cells are of enormous interest because of their general accessibility and potential to avoid ethical issues that are associated with embryonic stem cells. Also, adult stem cells are non immuno-compatible unless isolated from the same patient whereas ethical and scientific issues surrounding embryonic and fetal stem cells hinder their widespread implementation.en_US
dc.format.extentvii, 136p.en_US
dc.languageEnglishen_US
dc.relationen_US
dc.rightsuniversityen_US
dc.titleIslet neogenesis from non pancreatic stem cellsen_US
dc.title.alternativeen_US
dc.creator.researcherKadam, Sachin Sen_US
dc.subject.keywordBiotechnology, Diabetes, Stem cellsen_US
dc.description.noteAbstract includes, Bibliography p.95-132, Annexture p.133-136en_US
dc.contributor.guideBhonde, Ramesh Ren_US
dc.publisher.placePuneen_US
dc.publisher.universityUniversity of Puneen_US
dc.publisher.institutionNational Centre for Cell Scienceen_US
dc.date.registered0en_US
dc.date.completedMay, 2009en_US
dc.date.awarded2009en_US
dc.format.dimensionsen_US
dc.format.accompanyingmaterialDVDen_US
dc.type.degreePh.D.en_US
dc.source.inflibnetINFLIBNETen_US
Appears in Departments:National Centre for Cell Science

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01_title.pdfAttached File17.62 kBAdobe PDFView/Open
02_certificate.pdf43.31 kBAdobe PDFView/Open
03_declaration.pdf22.35 kBAdobe PDFView/Open
04_table of contents.pdf25.31 kBAdobe PDFView/Open
05_acknowledgement.pdf49.09 kBAdobe PDFView/Open
06_abstract.pdf53.17 kBAdobe PDFView/Open
07_abbreviations.pdf69.5 kBAdobe PDFView/Open
08_chapter 1.pdf543.05 kBAdobe PDFView/Open
09_chapter 2.pdf132.35 kBAdobe PDFView/Open
10_chapter 3.pdf993.04 kBAdobe PDFView/Open
11_chapter 4.pdf932.86 kBAdobe PDFView/Open
12_chapter 5.pdf736.81 kBAdobe PDFView/Open
13_chapter 6.pdf1.02 MBAdobe PDFView/Open
14_chapter 7.pdf83.36 kBAdobe PDFView/Open
15_bibliography.pdf201.75 kBAdobe PDFView/Open
16_annexture.pdf123.33 kBAdobe PDFView/Open


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