Developmental and Evaluation of programmed release buccal formulation of natural polyphenols

Abstract

The aim of the present work was to design and evaluate mucoadhesive buccal drug delivery systems of polyphenols from green tea The tea shoots are extremely rich in polyphenolic compounds the largest group being the flavanols which constitute up to 30 percentage on dry weight basis Several catechins are present in significant quantities and these are Epicatechin epigallocatechin Epicatechin gallate epigallocatechin gallate and catechin and gallo catechins Orally administered catechins has poor bioavailability due to extensive first pass metabolism and is degradation in gut wall The present research work programmed release buccal patches of catechin were designed using various mucoadhesive polymers and natural excipients in an effort to increase bioavailability Prior to the formulation of patches solubility of polymer and natural enhancer checked The effect of permeation enhancer on in vitro release and bioavailability of catechin was observed by buccal patches using pure catechin with extract of cassia fistula marigold oleoresin vinga radiata and in liposomal formulation Analytical methods were developed and validated for estimation of drug in different formulation like plain patches formulations stability in vitro and in vivo This in turn helped in selection of appropriate excipients Mucoadhesive buccal patches of catechin with natural permeation enhancer loading were prepared by solvent casting method Formulations were designed using varying proportions of various mucoadhesive and rate controlling polymers like hydroxypropyl methyl cellulose chitosan carboxy methyl cellulose The designed buccal patches were evaluated for the physical characteristics such as drug content thickness folding endurance swelling index bioadhesiestrength surface pH invitro release studies and mucoadhensive time In vivo drug release studies were performed using in rabbits newline newline newline