Effect of yoga on ambulatory glucose profile in type 2 diabetes mellitusI

Abstract

Management of diabetes and its complications are laying a huge burden in the newlineeconomy of developing nations like India, with the annual expenditure for the newlinemanagement of diabetes accounting to US$ 727 billion, of which major portion is spent newlineon the direct and indirect costs related to the complications of diabetes. There is newlinegrowing interest in alternative and holistic model of care which is evidence-based. Yoga newlineis a mind/body practise which is increasingly used in the management of many modern newlinenon-communicable diseases (NCDs) including type 2 diabetes and its complications. newlineGlycemic variability is an emerging target for diabetes management, along with HbA1C newlineand plasma glucose levels. Glycemic variability is known to induce excessive oxidative newlinestress and is an independent risk factor for the complications of diabetes and increased newlinerisk of mortality. newlineAIM AND OBJECTIVES newlineTo study the effect of yoga on glycemic variability and mean daily glucose newlinelevels in patients with type 2 diabetes in comparison to the active control group newline(walking). The objectives were to study the effect of (i) Intraday variability (ii) Interday newlinevariability and (iii) mean daily glucose levels. newlineMETHODS newlineParticipants newlineA total of 60 participants with diagnosed type 2 diabetes with HbA1C between newline7% - 8.5% were recruited for the study from a private diabetes specialty hospital in newlineChennai. newlineDesign newlineParticipants were randomly assigned either to the intervention group or the newlineactive control group of walking using a computer generated block randomisation, with newlinesix participants per block. Allocation concealment was carried out using sequentially newlinenumbered opaque sealed envelope (SNOSE), maintained by a person who was not newlinedirectly involved in the project. newlineAssessments newlineContinuous glucose monitoring (CGM) was carried out using flash glucose newlinemonitoring system, Freestyle Libre Pro (Abbott Diabetes Care Ltd., Oxon, UK), applied newlineon the non-dominant backside upper arm of the participants, which measures glucose newlinelevels every 15 minutes for a period of 14 days continuousl