Estrogenic effects of in silico designed isoflavone and deoxybenzoin derivatives on human cancer cells

Abstract

Estrogens are key regulators of human reproductive physiology acting through estrogen receptors In humans there are two major estrogen receptor subtypes and they are estrogen receptor alpha and estrogen receptor beta Xenoestrogens are non endogenous compounds having pharmacophoric features similar to that of estrogen, can bind to cellular ERs and cause agonistic or antagonistic outcomes Many of the xenoestrogens are useful as therapeutic agents for conditions such as hormone replacement therapy menopausal symptoms cancers of the breast ovary and prostate etc Isoflavones and deoxybenzoins are related class of compounds having some affinity for ERs and thereby exhibiting estrogenic effects in mammalian cells Some of the IFs and DOBs are potentially therapeutic for conditions such as prostate cancer and breast cancer This study was aimed at designing some novel IFs and derivatives DOBs and evaluating their estrogenic potential Of particular interest was to investigate the ability of these novel compounds to modulate the proliferation of human prostate cancer cells and breast cancer cells