Formulation and evaluation of controlled release solid lipid microparticles of candesartan cilexetil

Abstract

Solid lipid microparticles of controlled release Candesartan cilexetil SLM 1 to SLM 12 were prepared by fusion method using different ratios of lipophilic excipients such as hydrogenated castor oil stearic acid cetostearyl alcohol and carnauba wax The drug content and in vitro drug release of the prepared Candesartan cilexetil microparticles showed favourable drug content and satisfactory drug release The formulated solid lipid microparticles were further used for the development of controlled release compressed tablets and floating tablets of Candesartan cilexetil A total of 12 formulations of compressed tablets of Candesartan cilexetil were prepared by direct compression method and evaluated for physicochemical properties and in vitro dissolution All the prepared formulations showed almost uniform mass, thickness and drug content and also indicated excellent mechanical strength The in vitro release studies of compressed tablets of Candesartan cilexetil provided that the formulations prepared with cetostearyl alcohol showed maximum drug release in a controlled manner when compared to all other formulations prepared with hydrogenated castor oil stearic acid and carnauba wax