A Study to Find the Correlation of Neurophysiological Changes with Body Mass Index and Lipid Profile in Healthy and Type II Diabetes Mellitus Subjects

Abstract

There is a world-wide increase in the prevalence of Diabetes Mellitus. Type II Diabetes mellitus (TIIDM) is the most common presentation of the disease accounting for almost 90% of all diabetes cases worldwide. Type II Diabetes mellitus is associated with obesity, dyslipidemia, increase risk for peripheral neuropathy. In assessment of diabetic peripheral neuropathy, body mass index is very important factor to be taken into consideration. newline newlineThe present study was performed on 345 cases (TIIDM subjects) who recruited from OPD of the Department of Medicine, National Institute of Medical Sciences and research, NIMS University Rajasthan, Jaipur and 345 controls. BMI was determined, lipid profile was done on fully auto analyzer HUMA star 200 in biochemistry lab and Nerve conduction studies (NCS) in department of physiology of all the subjects. Medicaid System s EMG/NCV equipment with Neurostim software was used for nerve conduction velocity. newline newlineThe differences of nerve conduction studies show significant results in controls and cases. The significant effect was seen on amplitude of sensory and motor nerve was seen in cases. No correlation No correlation was seen in all variables of sensory and motor nerve in overweight and obese cases. Serum total cholesterol and triglyceride had significant positive correlation with latency but negative correlation with amplitude and conduction velocity of both sensory and motor nerve in cases. Serum high density lipoprotein had significant negative correlation with latency and positive correlation with amplitude and conduction velocity of nerves in cases. newline newlineSo this study demonstrated that various parameters of nerve conduction study can be affected by BMI and Lipid profile to some extent. So, these factors have also to be taken into consideration while interpreting nerve conduction studies in Type II Diabetic patients. newline newlineKeywords - Type II Diabetes mellitus, Nerve conduction studies, Body mass index newline newline