Population pharmacokinetics of doxophylline in patients with bronchial asthma Abstrac

Abstract

This research work illustrates the population pharmacokinetics of oral doxophylline DOXO in bronchial asthma patients using a modeling approach The study also aimed to identify and evaluate the role of covariates affecting inter individual variability Blood samples were collected from 109 patients and DOXO concentrations were analyzed from archived serum samples Population PK modeling was performed using Phoenix NLME 6dot2 The model used to describe the DOXO pharmacokinetics is a two compartment pharmacokinetic model following first order absorption and elimination Boot strapping and visual predictive check methods were implied for model evaluation The estimated value of clearance CL and CL2 were 2dot49 and 5dot19 L per h with an inter individual variability of 1dot3 and 4dot8 percentage respectively The estimated value of volume of distribution V and V2 were found to be 5dot6 and 30dot2 L with an inter individual variability of 11dot6 and 11 percentage respectively The absorption rate constant was calculated as 1dot59 per h with an inter individual variability of 8dot5 percentage Gender smoking habit and co morbid diabetes were identified as significant covariates affecting the clearance of DOXO 2Log likelihood profiling method indicated that the kinetic parameters could be estimated with good precision Boot strap and visual predictive check model qualification methods proved that the developed model sufficiently described the data observed This is the first ever population pharmacokinetic study of DOXO in Indian patients A population pharmacokinetic model from the observed data was developed for doxophylline successfully newline