Screening for Thyroid Dysfunction in Diabetic Population at Saharanpur India

Abstract

Diabetes mellitus (DM) and thyroid diseases are two common endocrinopathies seen in general population. The relationship between diabetes mellitus and thyroid dysfunction has not been demonstrated in Western Uttar Pradesh although the prevalence of diabetes mellitus is very high and increasing. Due to the lack of adequate information about two conditions, newlinepreventive management is difficult to plan and yet there could be many diabetic patients who may have thyroid dysfunction which may greatly affect their glycemic control. Malfunctions like thyroid diseases which can occur in diabetes mellitus and that causes metabolic disturbances can further complicate management of patients and escalate the cost of diabetes mellitus treatments.The present study is an attempt to examine the frequency of thyroid disease in patients with diabetes mellitus and to study the effect of diabetes on thyroid hormone level and other biochemical variables in population. In addition an attempt was made to evaluate the association between thyroid dysfunction and dyslipidemia, renal and liver disorder and glycosylated haemoglobin in diabetic subjects. Finally HbA1C was studied for its correlation with thyroid hormones, lipid profile, renal profile and liver newlinefunction. To meet the above objectives a total of 200 subjects including 100 diabetic (20 type 1 and 80 type 2) and 100 non diabetic controls subjects were included in the present study. Each patient was investigated for fasting plasma glucose (FPG), glycosylated haemoglobin(HbA1c), cholesterol, triglyceride, 2 high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), blood urea, creatinine, serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT),total triiodthyronine (T3),total thyroxine(T4),free triidothyronine (FT3), free thyroxine (FT4) and (TSH).