Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/235653
Title: Studies on improvement of physicomechanical and pharmacokinetic parameters of non steroidal anti inflammatory drugs by crystal engineering
Researcher: Vaghela, P.D.
Guide(s): Tank, H.M.
Keywords: Aqueous solubility
Clinical Pre Clinical and Health,Pharmacology and Toxicology,Pharmacology and Pharmacy
Compressibility
Flowability
Heckle plot
Ibuprofen
Ketoprofen
Pharmacokinetic parameters
Physicomechanical property
Processing parameters
University: RK University
Completed Date: 2018
Abstract: quotBackground: There are certain key issues in the pharmaceutical newlineindustries like poor physicochemical, mechanical and processing parameters newlinerather than toxic effect or non-efficacy of the medicaments which bring less newlinethan 1% of active medicaments into the market. Among these processing newlineproblems, aqueous solubility remains a key issue. Active pharmaceuticals are newlineoften rejected during commercial production due to their poor aqueous newlinesolubility and also poor mechanical properties. newlineAim: Aim of the present study was to improve physicochemical and mechanical newlineproperties of BCS Class-II drugs, Ibuprofen and Ketoprofen, of Non-steroidal newlineAnti-inflammatory Drugs (NSAIDs) category, with poor flow, using crystal newlineengineering approach for remarkable improvement in aqueous solubility, drug newlinerelease rate, manufacturing and pharmacokinetic parameters. newlineMaterials and Methods: Influence of various excipients and method of newlinepreparations were studied separately for both drugs by changing molar ratio of drug:excipient. Treated crystals of both drugs were studied for Heckel newlineparameters showed greater plastic deformation and tensile strength with newlinenegligible elastic recovery compared to respective pure drug which enables to newlineformulate directly compressible tablets of both treated crystals without using newlineany directly compressible excipients. The molar ratio which shows greater newlineaqueous solubility, drug release rate, drug loading efficiency, and % yield was newlineselected as an optimized batch for further study. newlineResults and Discussion: SEM images of both treated crystals showed shape newlinewith an aspect ratio near to unity with improved flow, packability, compactibility newlineand compressibility parameters. FT-IR and DSC study revealed no interaction newlineoccurred between drug and excipient in their physical mixture. DSC of treated newlinecrystals depicted endothermic transition occurred which demonstrates the newlinestability of new crystal form of both drugs and indicates the absence of newlineunbound/ absorbed solvent. pXRD of treated crystals of both drugs suggested newlinethe generation of
Pagination: 247p.
URI: http://hdl.handle.net/10603/235653
Appears in Departments:Faculty of Pharmacy

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01_title page.pdfAttached File77.12 kBAdobe PDFView/Open
02_certificate.pdf216.79 kBAdobe PDFView/Open
03_declaration.pdf272.19 kBAdobe PDFView/Open
04_acknowledgement.pdf1.73 MBAdobe PDFView/Open
05_table of contents.pdf4 MBAdobe PDFView/Open
06_list of tables.pdf1.64 MBAdobe PDFView/Open
07_list of figures.pdf1.3 MBAdobe PDFView/Open
08_list of abbreviations & symbols.pdf402.49 kBAdobe PDFView/Open
09_abstract.pdf673.01 kBAdobe PDFView/Open
10_chapter 1.pdf11.96 MBAdobe PDFView/Open
11_chapter 2.pdf10 MBAdobe PDFView/Open
12_chapter 3.pdf199.29 kBAdobe PDFView/Open
13_chapter 4.pdf13.18 MBAdobe PDFView/Open
14_chapter 5.pdf29.87 MBAdobe PDFView/Open
15_chapter 6.pdf418.13 kBAdobe PDFView/Open
16_chapter 7.pdf7.43 MBAdobe PDFView/Open
17_list of publications.pdf191.77 kBAdobe PDFView/Open
18_annexures.pdf1.85 MBAdobe PDFView/Open
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