Novel Synthetic and Biological Studies on Benzothiazoles_ Benzimidazoles Oxazolidinones and Pyrazolopyrimidine

Abstract

Heterocyclic compounds are important building blocks used to build up compounds of biological or medicinal chemistry interest to chemists. A huge number of heterocyclic building blocks have applications in pharmaceutical research, agriculture, and drug discovery. Keeping in view of the importance of the hetero cyclic ring containing compounds, in the present thesis describes the synthetic and biological studies on some of the important category of drug substances particularly Benzothiazole , Benzimidazole ,oxazolidinones and pyrazolopyrimidine containing hetero cyclic ring. Here the thesis containing research work on novel benzothiazole scaffolds , new synthetic method for the preparation of benzimidazole has been developed using a new catalyst Gd (OTf) 3 under microwave irradiation, C-ring modified and C-5 Substituted new oxazolidino amide/sulfonamides conjugates and the ultrasound assisted synthesis of a series of 2- alkynyl pyrazolo[1,5-a] pyrimidine derivatives . The total work carried out in the present research programme is being presented in six chapters. newline