Enantioselective Total Synthesis of 5_O_Feruloyl_2_Deoxy_D_ Ribono_and#915;_Lactone Key Intermediate Of _ _Verrucosapyrone A Lurasidone Hydrochloride Intermediate And Microwave Assisted One_Pot Synthesis of N_Acetyl Bisindoles

Abstract

Natural products often have therapeutic benefit as medicines for treating diseases, providing knowledge to synthesize active compounds as lead compounds for drug discovery. Organic chemists inspired with this knowledge and prepare them synthetically as total synthesis or partly synthesis of natural products. While synthesizing the natural products in novel routes organic chemists encountering many challenges towards the low selectivity, strong conditions, using catalysts, lesser yields and getting purities. Particularly in first total synthesis, the establishment of the route by retaining the stereochemistry would be a big challenge. And the development of smaller subunits or key intermediates of the existing drug moieties which are the main cost contributors in the total cost of drugs has great importance in the organic synthesis. Synthesis of these key intermediates in cost-effective route and achieving in the enantioselective route is challenging. On the other hand, there are many methodologies were in practice to prepare bis indolyl methane compounds. The reported methodologies for the preparation of bis indolyl methane derivatives having some shortcomings were observed like low yields, multi-step synthesis, longer reaction times, uses of metal or non-metal catalysts and commercially non-viable reagents. And facing issues in the N-acylation of the bis indolyl methanes were not reported. newline newlineFor this purpose research work concentrated towards the development of new synthetic approaches for the natural products such as 5-O-feruloyl-2-deoxy-D-ribino- and#947;- lactone and key intermediate of (-)-Verrucosapyrone A. As the synthesis of these natural products are not reported in literature and these natural products are having the stereocentres we intend to develop the first total synthesis in enantioselective routes with inexpensive chiral pool materials.