Synthesis and cyclic voltametric reduction of n hydroxyl 2 6 diaryl 3 Alkylpiperidin 4 one semicarbazones and thiosemicarbazones and the antimicrobial study of the products

Abstract

In this research work a series of N hydroxyl 3 alkyl 2 6 diarylpiperidin 4 one semicarbazones and N hydroxyl 3 alkyl 2 6 Diarylpiperidin 4 one thiosemicarbazones were synthesized The N hydroxyl 3 alkyl 2 6 diarylpiperidin 4 one semicarbazones and thiosemicarbazones were obtained by the reaction between 3 alkyl 2 6 diarylpiperidin 4 one and m chloro perbenzoic acid Semicarbazones and thiosemicarbazones are widely used as reactive intermediates in many organic syntheses The synthesised N hydroxy 3 alkyl 2 6 diarylpiperidin 4 one semicarbazones and thiosemicarbazones were subjected to cyclic voltammetric analysis using graphite electrode with variable scan rate A three electrode combination system was used This consisted of graphite working electrode and saturated calomel electrode SCE as reference electrode and platinum as an auxiliary electrode The working electrode potential was fixed slightly more than that was required for micro electrolysis The cyclic voltammetric behaviour of 0 01M of semicarbazone dissolved in mixed solvent of 0 1M of ethanol and distilled water was studied in the potential range of 2200mV to 2200mV and the variable scan rates range of 100mVs 1 150mVs 1 and 200mVs 1 Similar cyclic voltammetric behaviour was also observed for thiosemicarbazones The positions and shape of the peaks were dependent on the scan rate but the number of peaks was same As the number of stop crossing level increased, the number of peaks doesn t change which indicated irreversible reduction has taken place in the N hydroxyl 3 alkyl 2 6 diphenylpiperidin 4 one semicarbazones and thiosemicarbazones It was also found that the peak current for the semicarbazones and thiosemicarbazones were higher due to the reduction potential shifted towards more negative value newline