Studies on genetic and molecular aspects of scribble knockdown induced tumor progression mitochondrial dysfunction and its alleviation by Isatin derivatives in Drosophila cancer model

Abstract

The term Cancer is derived from a Greek word Karkinos by a physician Hippocrates around 460-370 B.C for carcinoma-tumors. Cancer has a very old history as evidenced by the presence of bone-cancer in mummies and a recorded case of breast cancer from the ancient Egypt in 1500 B.C (Sudhakar, 2009; Faguet, 2015). Cancer is a complex genetic disease, which can affect nearly every organ/system in the human body and one of the leading causes of human-mortality globally. World Health Organization (WHO) has estimated around 11 million deaths from cancer worldwide by 2030 (Stefenatos et al., 2011). In general, cancer can be defined as uncontrolled cell-proliferation leading to growth of mass of cells, called tumor/lumps. Sustained cell-proliferation and evading apoptotic-signals are the characteristic hallmarks of growing tumor (Hanahan et a.l, 2011). Tumor can be classified in two classes as benign and malignant (Idikio, 2011). newline