Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/222928
Title: | To Investigate Effect of Some Hepatoprotectiveagents on Drug Induced Hepatotoxicity in Albino Rats |
Researcher: | Dass Ervilla |
Guide(s): | Sattigeri B. M. |
Keywords: | Clinical Pre Clinical and Health,Pharmacology and Toxicology,Substance Abuse drugs |
University: | Suamandeep Vidyapeeth University |
Completed Date: | 2018 |
Abstract: | Introduction: Drug induced hepatotoxicity is a potential adverse effect, contributing to the health burden, with several mechanisms involved in causing liver injury. Many drugs and ingested substances cause the problem, with few drugs available for the treatment. Hence, we aimed to evaluate the hepatoprotective effect of certain hepatoprotective agents. newlineMaterial and Methods: Diclofenac (72, 96 and 240 mg/kg) was administered orally to evaluate its per se effect. Further, DL-Methionine (700 and 1400 mg/kg) and NAcetylcysteine (450 mg/kg), were also evaluated for per se effect, followed by evaluation of their hepatoprotective effect against the Diclofenac-induced hepatotoxicity (96 and 240 mg/Kg, single oral dose) in the albino rats. newlineObservations and Results: Diclofenac (96 and 240 mg/kg, single oral dose) per se, was found to be hepatotoxic, while DL-Methionine (700 and1400 mg/kg), and NAcetylcysteine (450 mg/kg) though altered the liver enzymes levels it was not significant, hence they were found not to be hepatotoxic. Both DL-Methionine and N-Acetylcysteine in above doses significantly protected the animals against the Diclofenac-induced hepatotoxicity. However, no statistical difference was found between the hepatoprotective effect of DL-Methionine and NAcetylcysteine. newlineConclusion: Both DL-Methionine and N-Acetylcysteine have been hepatoprotective newline newline |
Pagination: | 175 p. |
URI: | http://hdl.handle.net/10603/222928 |
Appears in Departments: | Department of Pharmacology |
Files in This Item:
File | Description | Size | Format | |
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01. title page.pdf | Attached File | 113.47 kB | Adobe PDF | View/Open |
02. certificate.pdf | 545.12 kB | Adobe PDF | View/Open | |
03. preliminary pages.pdf | 669.25 kB | Adobe PDF | View/Open | |
04 chapter-1 introduction & aims & objecties.pdf | 361.28 kB | Adobe PDF | View/Open | |
05. chapter-2 review of literature.pdf | 611.85 kB | Adobe PDF | View/Open | |
06. chapter-3 materials & methods.pdf | 631.91 kB | Adobe PDF | View/Open | |
07. chapter-4 results.pdf | 1.14 MB | Adobe PDF | View/Open | |
08. chapter-5 discussion.pdf | 354.42 kB | Adobe PDF | View/Open | |
09. chapter-6 conclusion.pdf | 272.23 kB | Adobe PDF | View/Open | |
10. chapter-7 bibliography.pdf | 517.49 kB | Adobe PDF | View/Open | |
11. list of publicatons.pdf | 738.5 kB | Adobe PDF | View/Open | |
plagiarisum check report.pdf | 49.88 kB | Adobe PDF | View/Open |
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