Chemopreventive Effects of Bee Propolis and its Constituents on Hepatocarcinogenesis and their Role in Modulation of Methotrexate toxicity

Abstract

The main emphasis of this thesis is the assessment of therapeutic potential of naturally occurring plant product, Bee Propolis and its constituents namely chrysin and chlorogenic acid against hepatotoxicity induced by Methotrexate (MTX), an anticancer drug in animal model as well as the role of bee Propolis and its constituents, chrysin and chlorogenic acid was evaluated against DEN initiated and 2-AAF promoted 2 stage hepatocarcinogenesis model in Wistar Rats. newlineThe results of our thesis supported by strong published literature reports suggest these natural compounds to be a potential candidate for prevention of chemically induced hepatotoxicity and hepatocarcinogenesis, since they restrain numerous biomarkers of oxidative stress, inflammation, apoptosis and tumor promotion in wistar rats. Further detailed mechanistic studies are necessary to reveal the useful effect of these naturally compounds before proceeding for clinical trials. newline