Formulation evaluation and development of bioadhesive drug delivery system containing phytopharmaceuticals

Abstract

A reservoir type patch of 18 and#946;-glycyrrhetinic acid and matrix type transdermal patch of boswellic acids with piperine as bioenhancer was prepared. Both type of patch were evaluated for physicochemical characteristics, in-vitro, ex-vivo and in-vivo studies. Reservoir F4 patch provided 95.55% in-vitro and 91.58% ex-vivo release of phytopharmaceutical at 10hr. The matrix F10 patch was showed 97.8% in vitro and 93.20% ex vivo release at 10 hr. The anti-inflammatory action of F4 (reservoir) and F10 (matrix) showed 87.36% and 89.77% inhibition of rat paw edema at 10 h. Both type of patch was demonstrated the feasibility for future clinical trials. newline