Evaluation of radioprotective potential of some bioflavonoids in mice exposed to gamma radiation

Abstract

Ionizing radiation is considered as a potent carcinogen. It is injurious to living newlineorganisms, as it induces oxidative stress. To protect against such injuries, it is necessary newlineto screen radioprotecitve agents that are non-toxic and can protect if administered after newlineradiation exposures. Flavonoids are polyphenolic compounds containing a unique newlinestructure (diphenyl propane structure). Recently, flavonoids have attracted attention newlinebecause of their antioxidant role. Bioflavonoids Rutin and Quercetin have been newlinedemonstrated as potent anti-inflammatory in a number of animal studies. To investigate newlinethe possible role of Rutin (RUT) and Quercetin (QRT) as radioprotectors following newlinestudies have been carried out. newlinePreliminary studies revealed that RUT (10mg/kg body weight) and QRT newline(20mg/kg body weight) when administered orally for five consecutive days prior to newlinegamma irradiation (IR) could protect about 70% of the animals for more than 30 days newline(period of observation) as assessed by their survival. newline