Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/204422
Title: | Development and Evaluation of Proniosomes Incorporated Transdermal Drug Delivery Systems for Ketorolac Tromethamine |
Researcher: | Mr. Nadeem Farooqui |
Guide(s): | Dr. Ravindra Pal Singh, Dr. Mousumi kar |
University: | Suresh Gyan Vihar University |
Completed Date: | 2018 |
Abstract: | newline The main aim of present research work is to prepare Proniosomal (PN) gel containing Ketorolac Tromethamine (KT) for anti-inflammatory and analgesic effect which gives prolong release in the systemic circulation. newlineThe PN gel was prepared by first optimization of proniosomal suspension and then it s converted to gel formulation. Proniosomes containing soya lecithin which having unsaturated fatty acid like oleic acid and linoleic acid showed penetration enhancing properties. And presence of cholesterol made the proniosomes more stable with high retention properties of vesicles. newlineOptimized PN suspension formulation B-1 made of nonionic surfactant (sodium cholate), produce stable proniosomes. Among the various formulation, proniosomal vesicles formulation B-1 (Ch-LCI-1) which based on sodium cholate shows higher permeability as compared to other proniosomal suspension formulation which were based on sodium deoxycholate and span 60. newlineIn the research work it was investigated practically that as the concentration of non-ionic surfactant decreases the entrapment efficiency of formulation increases hence formulation based on sodium cholate B-1 (Ch-LCI-1) contain lowest concentration of non-ionic surfactant shows the highest entrapment efficiency. Further PN gel was prepared from optimized formulation of proniosomal suspension B-1 (based on sodium cholate) which shows the highest drug release in sustained manner and drug permeability properties among the other proniosomal suspension. newlineBy using various concentrations of penetration enhancers and carbopol gel base in formulations were examined in order to enhance the permeation and delayed release of KT in systemic circulation. On the basis of studies, optimized proniosomal gel (F-1) to forms niosomes after mixing with skin secretions in-vivo or mixing with diffusing receptor fluid in-vitro before delivering the drug into and through the skin. And enhanced transdermal delivery of drug is caused by vesicle formation. newlineDrug is transferred from proniosomes due to pene |
Pagination: | |
URI: | http://hdl.handle.net/10603/204422 |
Appears in Departments: | Department of Pharmacy |
Files in This Item:
File | Description | Size | Format | |
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10. literature review _chapt. 3.pdf | Attached File | 445.71 kB | Adobe PDF | View/Open |
11. plan of work_chapt. 4.pdf | 302.1 kB | Adobe PDF | View/Open | |
12. drug and excipient profile_chapt. 5.pdf | 684.48 kB | Adobe PDF | View/Open | |
13. experimental work_chapt. 6.pdf | 1 MB | Adobe PDF | View/Open | |
14. results & discussion_chapt. 7.pdf | 1.91 MB | Adobe PDF | View/Open | |
15. conclusion_chapt. 8.pdf | 284.99 kB | Adobe PDF | View/Open | |
16. bibliography_chapt. 9.pdf | 564.85 kB | Adobe PDF | View/Open | |
17. list of publication_chapt. 10.pdf | 426.03 kB | Adobe PDF | View/Open | |
1. title page.pdf | 166.03 kB | Adobe PDF | View/Open | |
2. list of certificate.pdf | 650.15 kB | Adobe PDF | View/Open | |
3. list of content.pdf | 174.25 kB | Adobe PDF | View/Open | |
4 list of tables.pdf | 166.85 kB | Adobe PDF | View/Open | |
5. list of figures.pdf | 192.58 kB | Adobe PDF | View/Open | |
6. list of abbreviation.pdf | 207.12 kB | Adobe PDF | View/Open | |
8. introduction_chapt. 1.pdf | 1.11 MB | Adobe PDF | View/Open | |
9. scope and objective _chapt.2.pdf | 285.77 kB | Adobe PDF | View/Open |
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