Synthesis of Heterocyclic Molecules as Potential Anti Alzheimeric Agents

Abstract

Alzheimer s disease (AD) has a destructive impact on society, healthcare and cost. It is the most common form of dementia, which mainly occurs in elderly aged people. The disease affects cognitive function of patient. An approximately 9.4 million Americans are affected by this disease and this number is increased up to 30 million in 2050. While in Asia 23 million people suffered from this disease and this number is increase up to 38 million in 2030 and 67 million in 2050. The human cost is incalculable, the financial burden of caring for these patients is now $150 billion a year in America and the crisis is spreading. From Indian perspective, in the late nineties, of about 820 million people in the country, about 8.5% (and#61566; 70 million people) were over 60 years of age. Today, this population increased to 10% and by the year 2021, this is expected that every seventh Indian will be a senior citizen. In 2010, there are 3.7 million Indians with dementia and the total societal costs is about 14,700 crore. While the numbers are expected to double by 2030, costs would increase three times. It is the sixth leading cause of death in USA and 5 leading cause of death for those people who aged above 60. The cause and progression of AD is not well understood till now. Based on the ongoing research several hypothesis are given for the treatment of AD at early stage but, till now no drugs are available which permanently cure this disease. There are only few drugs are available which is mainly based on the cholinergic hypothesis and was approved by FDA, used for the treatment of AD at early stage. These known drugs not cure the disease permanently, they only slow down the progression of this disease. Some of these drugs have side effect also which a major problematic issue for the elderly aged people. Based ongoing research and hypothesis available for the treatment of AD, herein we have design, synthesize and evaluated some novel heterocyclic molecule based on coumarin, thiazole and trialzole moieties to obtain a lead novel molecu