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http://hdl.handle.net/10603/199913
Title: | DEVELOPMENT AND IMPLEMENTATION OF STRATEGIES TO PREVENT OR MINIMIZE ADVERSE DRUG REACTIONS TO ANTIRETROVIRAL MEDICATIONS IN TREATMENT NAiVE HIV PATIENTS |
Researcher: | Adusumilli Pramod Kumar |
Guide(s): | G Parthasarathi |
Keywords: | HIV, AIDS, Antiretroviral therapy, Adverse drug reactions |
University: | JSS University |
Completed Date: | 12/02/2018 |
Abstract: | Background: Incidence of adverse drug reactions (ADRs) to antiretrovirals (ARVs) is constantly increasing. Objective: To identify the ADRs to ARVs in HIV patients and to develop and implement the strategies to prevent or minimize ADRs associated with ARVs. Methodology: An ambispective observational study was conducted at HIV care hospital over a period of 18 months to identify, assess and document the ADRs to ARVs. Based on this, strategies were developed and implemented by conducted prospective interventional study. Results: Out of 1050 patients reviewed, 380 patients experienced 440 ADRs with an incidence of 36.2%. Predictable reactions accounted for 95% (n=419) and 25% (n=109) were not preventable. Strategies like adding cinnarizine to patients started with T+L+E regimen to prevent dizziness, ranitidine with Z+L+N regimen to prevent gastritis, and hydroxychloroquine (HCQ) in patients with TB-IRIS. Out of 300 patients receiving T+L+E regimen, 22.6% were experienced ADRs in the interventional group (given with cinnarizine + patient counseling) compared to 36% among non-interventional group. Out of 100 patients receiving Z+L+N regimen, 18% were experienced with ADRs in the interventional group (given with ranitidine + patient counseling) compared to 28% among non-interventional group. Among 40 patients with TB-IRIS given with HCQ, 33 (82.5%) patients were improved symptomatically. Conclusion: The overall incidence of ADRs among HIV patients was found to be 36.2%. Implementation of the strategies was found to be useful to prevent or minimize dizziness in patients receiving T+L+E regimen and gastritis in patients receiving Z+L+N regimen. In paradoxical TB-IRIS patients, symptoms were minimized with the administration of HCQ. newline |
Pagination: | I-X, 1-79p |
URI: | http://hdl.handle.net/10603/199913 |
Appears in Departments: | College of Pharmacy |
Files in This Item:
File | Description | Size | Format | |
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10. chapter iii - objectives.pdf | Attached File | 16.43 kB | Adobe PDF | View/Open |
11. chapter iv - review of literature.pdf | 70.52 kB | Adobe PDF | View/Open | |
12. chapter v - methodology.pdf | 107.86 kB | Adobe PDF | View/Open | |
13. chapter vi - results.pdf | 295.78 kB | Adobe PDF | View/Open | |
14. chapter vii - discussion.pdf | 56.16 kB | Adobe PDF | View/Open | |
15. chapter viii - conclusion.pdf | 10.12 kB | Adobe PDF | View/Open | |
16. chapter ix - reference.pdf | 92.25 kB | Adobe PDF | View/Open | |
1. title of the study.pdf | 21.1 kB | Adobe PDF | View/Open | |
2. certificates.pdf | 351.32 kB | Adobe PDF | View/Open | |
3. dedication.pdf | 12.89 kB | Adobe PDF | View/Open | |
4. acknowledgement.pdf | 25.33 kB | Adobe PDF | View/Open | |
5. list of abbreviations.pdf | 25.54 kB | Adobe PDF | View/Open | |
6. list of contents, tables, graphs and figures.pdf | 40.13 kB | Adobe PDF | View/Open | |
7. abstract.pdf | 32.19 kB | Adobe PDF | View/Open | |
8. chapter i - introduction.pdf | 54.32 kB | Adobe PDF | View/Open | |
9. chapter ii - need for the study.pdf | 18.24 kB | Adobe PDF | View/Open |
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