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http://hdl.handle.net/10603/199509
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DC Field | Value | Language |
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dc.date.accessioned | 2018-04-06T12:09:22Z | - |
dc.date.available | 2018-04-06T12:09:22Z | - |
dc.identifier.uri | http://hdl.handle.net/10603/199509 | - |
dc.description.abstract | Background: The anti-inflammatory action of Curcumin is already proven but its water insolubility and low bioavailability property limits its use to treat neuro inflammatory diseases. Novel formulation like microemulsion and nano formulations are explored to target the drug molecule to affected site. newline newlineAim: The investigation was aimed at developing an optimal mucoadhesive microemulsion and to evaluate its potential neuroprotective effect against dopaminergic inflammation mediated neurodegeneration using MPTP i.e., 1methyl-4-phenyl-1,2,3,6-tetrahydropyridine in Parkinsonism following transnasal application. newline newlineMaterials and Methods: Mucoadhesive microemulsion of Curcumin (CMME) was successfully optimized by Box-Behnken design by manipulating the combined influences of all formulation components on responses like average globule size, size distribution, viscosity, flux and drug permeation (%). CMMEs were characterized and assessed for ex-vivo naso mucosal permeation, nasal toxicity along with pharmacokinetic evaluations (Brain distribution study). Preclinical study in MPTP induced Male C57BL/6 mice model was also carried out to ascertain the neuroprotective action of optimal CMME. Finally, accelerated stability study of CMME was carried out for 6 months as per ICH guideline (Q8, R2). newlineConclusion(s): Data so obtained revealing the neuro-protective action of CMME against injury induced by MPTP in striatum as well as substantia nigra pars compacta (SNpc) and hence, this approach for brain targeting of Curcumin through intranasal route to treat PD is much more promising | - |
dc.language | English | - |
dc.rights | self | - |
dc.title | Pharmacokinetic and Pharmacodynamic evaluation of a novel formulation of Curcumin | - |
dc.creator.researcher | Mandal, Snigdha | - |
dc.subject.keyword | Box-Behnken design | - |
dc.subject.keyword | Curcumin | - |
dc.subject.keyword | Flux, Capmul MCM | - |
dc.subject.keyword | Male C57BL/6 mice | - |
dc.subject.keyword | MPTP | - |
dc.subject.keyword | Mucoadhesive Microemulsion | - |
dc.subject.keyword | Parkinsonism | - |
dc.subject.keyword | Response surface methodology (RSM) | - |
dc.subject.keyword | Pharmacy | - |
dc.contributor.guide | Patel, Jayvadan | - |
dc.publisher.place | Rajkot | - |
dc.publisher.university | RK University | - |
dc.publisher.institution | Faculty of Pharmacy | - |
dc.date.registered | 21/01/2012 | - |
dc.date.completed | 2017 | - |
dc.date.awarded | 14/10/2017 | - |
dc.format.dimensions | 28 cm. | - |
dc.format.accompanyingmaterial | None | - |
dc.source.university | University | - |
dc.type.degree | Ph.D. | - |
Appears in Departments: | Faculty of Pharmacy |
Files in This Item:
File | Description | Size | Format | |
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abstract.pdf | Attached File | 15.12 kB | Adobe PDF | View/Open |
acknowledgements.pdf | 10.74 kB | Adobe PDF | View/Open | |
certificates.pdf | 9.76 MB | Adobe PDF | View/Open | |
chepter_1 introduction.pdf | 281.14 kB | Adobe PDF | View/Open | |
chepter_2 objectives.pdf | 6.72 kB | Adobe PDF | View/Open | |
chepter_3 materials and methods.pdf | 100.74 kB | Adobe PDF | View/Open | |
chepter_4 results.pdf | 1.46 MB | Adobe PDF | View/Open | |
chepter_5 discussion.pdf | 30.95 kB | Adobe PDF | View/Open | |
chepter_6 summary and conclusion.pdf | 14.08 kB | Adobe PDF | View/Open | |
declaration.pdf | 24.57 kB | Adobe PDF | View/Open | |
graphical abstract.pdf | 158.17 kB | Adobe PDF | View/Open | |
list of figures.pdf | 11.62 kB | Adobe PDF | View/Open | |
list of symbols, abbreviations and nomenclatures.pdf | 10.98 kB | Adobe PDF | View/Open | |
list of tables.pdf | 11.42 kB | Adobe PDF | View/Open | |
references.pdf | 53.33 kB | Adobe PDF | View/Open | |
table of contents.pdf | 11.22 kB | Adobe PDF | View/Open | |
title page.pdf | 52.37 kB | Adobe PDF | View/Open |
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