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Title: Pharmacokinetic and Pharmacodynamic evaluation of a novel formulation of Curcumin
Researcher: Mandal, Snigdha
Guide(s): Patel, Jayvadan
Keywords: Box-Behnken design
Flux, Capmul MCM
Male C57BL/6 mice
Mucoadhesive Microemulsion
Response surface methodology (RSM)
University: RK University
Completed Date: 2017
Abstract: Background: The anti-inflammatory action of Curcumin is already proven but its water insolubility and low bioavailability property limits its use to treat neuro inflammatory diseases. Novel formulation like microemulsion and nano formulations are explored to target the drug molecule to affected site. newline newlineAim: The investigation was aimed at developing an optimal mucoadhesive microemulsion and to evaluate its potential neuroprotective effect against dopaminergic inflammation mediated neurodegeneration using MPTP i.e., 1methyl-4-phenyl-1,2,3,6-tetrahydropyridine in Parkinsonism following transnasal application. newline newlineMaterials and Methods: Mucoadhesive microemulsion of Curcumin (CMME) was successfully optimized by Box-Behnken design by manipulating the combined influences of all formulation components on responses like average globule size, size distribution, viscosity, flux and drug permeation (%). CMMEs were characterized and assessed for ex-vivo naso mucosal permeation, nasal toxicity along with pharmacokinetic evaluations (Brain distribution study). Preclinical study in MPTP induced Male C57BL/6 mice model was also carried out to ascertain the neuroprotective action of optimal CMME. Finally, accelerated stability study of CMME was carried out for 6 months as per ICH guideline (Q8, R2). newlineConclusion(s): Data so obtained revealing the neuro-protective action of CMME against injury induced by MPTP in striatum as well as substantia nigra pars compacta (SNpc) and hence, this approach for brain targeting of Curcumin through intranasal route to treat PD is much more promising
Appears in Departments:Faculty of Pharmacy

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