Effect of Swarna Bhasma and Kaseesa Bhasma on Reproductive Function in Female Rats

Abstract

newline Background newlineMany popular Ayurvedic drugs such as Swarna bhasma, Kaseesa bhasma etc. have newlinemultifarious properties. Present study has attempted to evaluate the effects or the mode of newlineaction of four Ayurvedic formulations i.e. Swarna Bhasma, Swarna Bhasma containing newlinecompound formulation, Kaseesa Bhasma and Kaseesa Bhasma containing compound newlineformulations on Reproductive System of the animal model. newlineObjectives newlinePrimary Objective newline To study the effect of Swarna Bhasma and Kaseesa Bhasma on Reproductive function newlinein female rats. newlineSecondary Objective newlineTo Study the effects of Swarna containing compound formulation and Kaseesa newlinecontaining compound formulation on reproductive function in female rats. newlineMethodology newlineAll drugs were purchased from the GMP Certified Ayurvedic Companies. Bhasma newlinesamples selected for the study were subjected to Classical bhasma tests (Parikshas), newlineNamburi Phased Spot Test XRD, SEM, FTIR and Modern ICPAES Analysis. newlinexx | newline newlineAnimal Study newlineApproval for Animal Study newlineApproval was taken from institutional Animal ethical committee with approval letter No newlineBMK/IAEC/Res-13/2012. newlineGuideline for Animal Study: OECD Series on Testing and Assessment Number 38 newline(Uterotrophic Bioassay) newlineAnimal Procurement: newlineAnimals were procured from JNMC registered breederLicence No- 627/02/a/CPCSEA newlineDated 19/06/2002 newlineand#61623; 30 Female Wistar strain albino rats of age 16-17 days of birth without newlineevidence of any physical abnormalities and weighing between 20±6gmwere newlineprocured from licensed breeder KLEU JNMC Animal House Belgaum. newlineand#61623; The day of the birth being considered as postnatal day 0. newlineand#61623; The animals were identified uniquely by marking. newlineand#61623; They were kept under conditions of controlled temperature 22±3 newlineQuarantine newlinehumidity minimum 30% and 12 hrs dark and light cycle, allowed to free access newlineto standard dry pellet diet and potable water. newlineAnimals were kept in quarantine for 1 day as per guidelines of Uterotrophic bioassay. newlinexxi | newline newline0 newlineC, relative newlineGrouping newline30 Female Wistar strain albino rats were randoml