Development and Evaluation of Bio Nanogels of Selegiline and Escitalopram for Brain Targeting through Ear

Abstract

newline The present aim of research work was to develop and evaluate selegiline and escitalopram loaded bionanogels intended to target brain through ear for the treatment of depression. Escitalopram and selegiline the model drug for current research work are both antidepressant agents. As these drugs have short halflife and show some serious side effects due to availability of drug at nontargeting site both of them demand a novel approach for delivery. newlineBionano formulations were prepared using different ratios of drugs selegiline and escitalopram and biopolymers collected from various natural sources. Bionano formulations were prepared by using modified solvent evaporation method. Prepared batches were projected to various evaluation studies and on the basis of them two formulations EC4 and SC5 were selected as optimized formulations and then bionanogels were prepared and further subjected to ex vivo release in vitro diffusion and stability studies. EC4 and SL5 had Particle size of 147.7 nm and below 140nm with 66 percentage and 75 percentage mean intensity PDI of 0.187 and 0.313 smooth surface releases 57.73 and 54.91percentage drug respectively during study period 87.44 and 97.11percentage drug entrapment value follow zero order kinetic model and obeyed nonfickian and case II diffusion respectively. On the basis of ex vivo study it was suggested that formulations were able to release drug at a same rate and extend in biological conditions. In vivo pharmacological screening and in vivo release study indicate that the prepared bionanogels formulations effectively reach brain through ear and provide an optimum concentration to produce desired therapeutic effect. Stability studies suggests that developed bio nanogels were physically and chemically stable which retain its properties for a period of 3 months at various environmental conditions. Further it can be said that selegiline and escitalopram loaded bio nanogels are effective in providing therapeutic efficacies. newline newline